Background The use of lengthy, detailed, and complex informed consent forms is of paramount concern in biomedical research as it may not truly promote the rights and interests of research participants. The extent of information in ICFs has been the subject of debates for decades; however, no clear guidance is given. Thus, the objective of this study was to determine the perspectives of research participants about the type and extent of information they need when they are invited to participate in (...) biomedical research. Methods This multi-center, cross-sectional, descriptive survey was conducted at 54 study sites in seven Asia-Pacific countries. A modified Likert-scale questionnaire was used to determine the importance of each element in the ICF among research participants of a biomedical study, with an anchored rating scale from 1 to 5. Results Of the 2484 questionnaires distributed, 2113 were returned. The majority of respondents considered most elements required in the ICF to be ‘moderately important’ to ‘very important’ for their decision making. Major foreseeable risk, direct benefit, and common adverse effects of the intervention were considered to be of most concerned elements in the ICF. Conclusions Research participants would like to be informed of the ICF elements required by ethical guidelines and regulations; however, the importance of each element varied, e.g., risk and benefit associated with research participants were considered to be more important than the general nature or technical details of research. Using a participant-oriented approach by providing more details of the participant-interested elements while avoiding unnecessarily lengthy details of other less important elements would enhance the quality of the ICF. (shrink)

While univariate functional magnetic resonance imaging data analysis methods have been utilized successfully to map brain areas associated with cognitive and emotional functions during viewing of naturalistic stimuli such as movies, multivariate methods might provide the means to study how brain structures act in concert as networks during free viewing of movie clips. Here, to achieve this, we generalized the partial least squares analysis, based on correlations between voxels, experimental conditions, and behavioral measures, to identify large-scale neuronal networks activated during (...) the first time and repeated watching of three ∼5-min comedy clips. We identified networks that were similarly activated across subjects during free viewing of the movies, including the ones associated with self-rated experienced humorousness that were composed of the frontal, parietal, and temporal areas acting in concert. In conclusion, the PLS method seems to be well suited for the joint analysis of multi-subject neuroimaging and behavioral data to quantify a functionally relevant brain network activity without the need for explicit temporal models. (shrink)

Electroacupuncture (EA) and electroconvulsive therapy (ECT) are often used in the management of schizophrenia. This study sought to determine whether additional EA and ECT could augment antipsychotic response and reduce related side effects. In this retrospective controlled study, 287 hospitalized schizophrenic patients who received antipsychotics (controls, n = 50) alone or combined with EA (n = 101), ECT (n = 55) or both (EA+ECT, n = 81) were identified. EA and ECT were conducted for 5 and 3 sessions per week, (...) respectively, with a maximum of 12 sessions for ECT during hospitalization. The Scale for the Assessment of Positive Symptoms (SAPS) and Scale for the Assessment of Negative Symptoms (SANS) were used to assess the severity of psychotic symptoms. Clinical response on SAPS and SANS, weight gain, and adverse events were compared. Survival analysis revealed that the ECT and EA+ECT groups had markedly greater clinical response rate than controls on SAPS [72.7% and 90.1% vs. 64.0%; relative risk (RR), 1.974 and 2.628, respectively, P ≤ 0.004] and on SANS (67.3% and 70.4% vs. 42.0%; RR, 1.951 and 2.009, respectively, P ≤ 0.015). A significantly greater response rate on SANS than controls was also observed in the EA group (64.4% versus 42.0%; RR = 1.938, P = 0.008). EA-containing regimens remarkably reduced weight gain and incidences of headache, insomnia, dry mouth, and electrocardiographic abnormalities. These results suggest that EA and ECT can serve as additional treatment for enhancing antipsychotic response and reduce the side effects in hospitalized patients with schizophrenia. (shrink)

Existential-Ontologie und historischer Materialismus bei Herbert Marcuse, von A. Schmidt.--Das Ganze und das ganz Andere; zur Kritik der reinen revolutionären Transzendenz, von W.F. Haug.--Technik und Eindimensionalität; eine Version der Technokratiethese? Von C. Offe.--Technologische Rationalität und spätkapitalistische ökonomie, von J. Bergmann.--Die geschichtliche Dimension des Realitätsprinzips, von H. Berndt und R. Reiche.--Marcuse and the New Left in America, by P. Breines.--Ausgewählte Bibliographie der Schriften Herbert Marcuses (p. 155-[161]).

Background Adherence to ethical guidelines and regulations and protecting and respecting the dignity and autonomy of participants by obtaining a valid informed consent form (ICF) prior to participation in research are crucial; The subjects did not add signatures next to the corrections made to signatures or dates on the ICF, Multiple signatures in other fields, ICF missing/missing signature, Incorrect ICF version Signed after modification, Correction tape used to correct signature, Impersonated signature, Non-research-member signature, however, ICFs are often not properly completed, (...) which must be addressed. This study analyzed ICF signing errors and implemented measures to reduce or prevent these errors. Methods We used the plan–do–check–act (PDCA) cycle to help improve the correctness and validity of ICF signing. Results Interim and final reports from January 2016 to February 2020 including 363 ICFs were studied. The total proportion of correct ICF signatures (200, 83.3%) following the PDCA intervention was significantly higher than that before the intervention (P < 0.05). Analysis of the types of signing error demonstrated that signature errors were significantly reduced after the intervention, particularly for subjects did not add signatures next to the corrections made to signatures or dates on the ICF (16, 6.7%) and impersonated signature (0; P < 0.05). Conclusions The proportions of other error types—multiple signatures in other fields, missing or unsigned ICF, incorrect signature order, incorrect ICF version, use of correction tape to correct signature, and non-medical profession members signing the ICF—did not differ significantly. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Monasticism, Buddhist and Christian: The Korean ExperienceJames A. Wiseman OSBMonasticism, Buddhist and Christian: The Korean Experience. Edited by Sunghae Kim and James W. Heisig. Louvain Theological and Pastoral Monographs 38. Leuven: Peeters; Grand Rapids: Eerdmans, 2008. 201 pp.In order to evaluate Monasticism, Buddhist and Christian properly, one must know something about its origin. The principal editor, Sunghae Kim, is director of the Seton Interreligious Research Center in Seoul, (...) a center that regularly sponsors interreligious dialogues at a scholarly level. In addition to those dialogues, the center also organizes a series of monthly lectures for the public at large, held each year around a specific theme. The chapters of this book were, with one exception, originally given in the 1995 lecture series and later translated from Korean into English. For that reason, most of the material will already be quite familiar to specialists in the Buddhist and Christian traditions and will at times seem to offer generalizations that would be accurate enough for presentations to the general public but would need various qualifications and nuances to meet the more rigorous standards of scholars.The first two chapters are broadly introductory. In the first, Sunghae Kim gives a brief overview of the renunciatory life in six major religions (Hinduism, Buddhism, Daoism, Judaism, Christianity, and Islam). She concludes that “in terms of strict renunciation of possessions, family, and pursuit of the ego, Hinduism, Buddhism, Christianity, and Daoism stand out” (p. 35), with Buddhism and Christianity in particular being characterized by highly developed forms of monasticism per se. Bernard Senécal, a Canadian Jesuit who teaches Buddhist studies at Sogang University in Seoul, wrote the following chapter, “Korean Buddhism Today and Its Encounter with Christianity,” specifically for this book. The eight chapters that follow are the heart of the book. Jaemoon Yun, the abbot of the Korean Buddhist monastery in Chung-ju, has chapters on the history of the Buddhist monastic precepts, on nonpossession and the use of property in the saṅgha, on the organizational structure of the saṅgha, and on the homeless life and the Buddhist practice of compassion. Following each of these four chapters is one by the Benedictine monk Thomas Timpte on the corresponding topic in Christian monastic life as found in the Roman Catholic Church. A short final chapter by Younghae Yun, a professor of Buddhist studies and comparative religion at Gongguk University in Kyeong-ju, highlights a few characteristics of Buddhist and Christian life. Rather than comment on material from each chapter, I [End Page 228] will discuss in this review three points that struck me as particularly interesting and/or controversial.At the beginning of the first of his four chapters, “The History and Spirit of Christian Monastic Rules,” Thomas Timpte rightly devotes several pages to clarifying terminology. The details need not concern us here, but in general monks and nuns in the Catholic Church make public profession of the “evangelical counsels” of poverty, celibacy (sometimes called chastity), and obedience; in addition, they practice some degree of enclosure (“separation from the world”) and (except for the relatively few who are hermits) live in community. Timpte notes that although there have been men and women who practiced the evangelical counsels since New Testament times, the formal institution of Christian monastic life arose in the eastern part of the Mediterranean only around the year 300. For that reason, he argues that monasticism cannot be considered central to the Church in an institutional sense, whereas monasticism was an essential part of Buddhism from the beginning, the Buddha himself and his earliest followers all having been monks. This is one of the points about which Younghae Yun disagrees with Timpte, for the Buddhist scholar claims that even though Buddhist monks and nuns, like their Christian counterparts, take vows (precepts), and in some sense live apart from society at large, such a way of life itself “is neither essential nor central” in Buddhism (p. 185). Younghae Yun bases his argument on the fact that the Buddha considered such practices as only “a means to achieve enlightenment” and that enlightenment itself is not the true raison d’être of Buddhism but is rather a way of facilitating... (shrink)

The criminal law presently distinguishes between actions and omissions, and only rarely proscribes failures to avert consequences that it would be an offense to bring about. Why? In recent years it has been persuasively argued by both Glover and Bennett that, celeris paribus, omissions to prevent a harm are just as culpable as are actions which bring that harm about. On the other hand, and acknowledging that hitherto “lawyers have not been very successful in finding a rationale for it,” Tony (...) Honoré has sought to defend the law's differential treatment. He proposes a “distinct-duties theory” that in addition to the general duties we owe to everyone, we also owe distinct duties to a more limited collection of people and associations, specified by features of our relationship with them. Where a distinct duty holds, breach by omission may well be no better than breach by positive action. But absent a distinct duty, omissions, per Honoré, are less culpable. They are mere failures to intervene and improve or rectify things, whereas actions are positive interventions which make things worse. And, thus, the law has good reason to differentiate between them. (shrink)

The paper considers the intellectual computer mathematics system InparSolver, which is designed to automatically explore and solve basic classes of computational mathematics problems on multi-core computers with graphics accelerators. The problems of results reliability of solving problems with approximate input data are outlined. The features of the use of existing computer mathematics systems are analyzed, their weaknesses are found. The functionality of InparSolver, some innovative approaches to the implementation of effective solutions to problems in a hybrid architecture are described. Examples (...) of applied usage of InparSolver for processes mathematical modeling in various subject areas are given. Nowadays, new more complex objects and phenomena in many subject areas are constantly emerging, which are subject to mathematical research on a computer. This encourages the development of new numerical methods and technologies of mathematical modeling, as well as the creation of more powerful computers for their implementation. With the advent and constant development of supercomputers of various architectures, the problems of their effective use, expansion of tasks range should be solved, ensuring the reliability of computer results and increasing the level of intellectual information support for users ‒ specialists in various fields. Today, the issues of solving these problems are given special attention by many specialists in the fields of information technology and parallel programming. The world's leadingscientists in the field of computer technology see the solution to the problems of efficient usage of modern supercomputers in algorithmic software creation that easily adapts to different computer architectures with different types of memory and coprocessors, supports efficient parallelism on millions of cores etc. In addition, improving the efficiency of high-performance computing on modern supercomputers is provided by their intellectualization, transferring to the computer to perform a significant part of the functions. The industry of development and usage of intelligent computer technologies is one of the main directions of science and technology development in modern society. (shrink)

We apply an online optimization process based on machine learning to the production of Bose-Einstein condensates. BEC is typically created with an exponential evaporation ramp that is optimal for ergodic dynamics with two-body s-wave interactions and no other loss rates, but likely sub-optimal for real experiments. Through repeated machine-controlled scientific experimentation and observations our ’learner’ discovers an optimal evaporation ramp for BEC production. In contrast to previous work, our learner uses a Gaussian process to develop a statistical model of the (...) relationship between the parameters it controls and the quality of the BEC produced. We demonstrate that the Gaussian process machine learner is able to discover a ramp that produces high quality BECs in 10 times fewer iterations than a previously used online optimization technique. Furthermore, we show the internal model developed can be used to determine which parameters are essential in BEC creation and which are unimportant, providing insight into the optimization process of the system. (shrink)

The ethical challenges of caring for the chronically ill are of increasing concern to nurses as they attempt to create humanitarian environments for long-term care. This article suggests two ethical perspectives to guide the agenda of the nursing profession to achieve social change in the care of the chronically ill and aging. First, a reemphasis on the public duties of the professions is recommended which extends beyond serving the interests of the nursing profession to recognizing the need to serve the (...) common good. Second, the limitations of the autonomy paradigm are explored and the foundation for the development of a new moral paradigm is analyzed in terms of its' potential usefulness in addressing ethical problems of chronic illness. Several initiatives that nursing must undertake to facilitate the emergence of this paradigm are proposed. (shrink)

This work considers the future of driving in terms of both its short- and long-term horizons. It conjectures that human-controlled driving will follow in the footsteps of a wide swath of other, now either residual or abandoned human occupations. Pursuits that have preceded it into oblivion. In this way, driving will dwindle down into only a few niche locales wherein enthusiasts will still persist, much in the way that steam train hobbyists now continue their own aspirational inclinations. Of course, the (...) value of any such prognostication is in direct proportion to the degree that information is conveyed, and prospective uncertainty reduced. In more colloquial terms: the devil is in the details of these coming transitions. It is anticipated that we will see a progressive transformation of the composition of on-road traffic that will be registered most immediately in the realm of professional transportation in which the imperative for optimization exceeds that in virtually all other user segments. The transition from manual control to full automation will be more punctate than gradualist in is evolutionary development. As performance optimization slowly exhausts the commercial sector, it will progressively transition more into the discretionary realm by dint of simple technology transfer alone. The hedonic dimension of everyday driving will be dispersed and pursued by progressively fewer individuals. The traveling window of generational expectation will soon mean that human driving will be largely ‘forgotten,’ as each sequential generation matures without this, still presently common, experience. Indications of this stage of progress are beginning to... (shrink)

В монографии раскрыта одна из современных концепций теории познания и онтологии – континуалистика. Рассмотрены гипотезы становления информационного подхода в естествознании. Показаны предпосылки формирования информационной химии, заданные рядом современных концепций и моделей. Сформулирована концепция химической континуалистики, предстающей в качестве специальной дисциплинарной онтологии, которая восходит к линии «непрерывной химии нормальных состояний». Проведена демаркация онтологического, гносеологического и социологического аспектов становления информационной, континуальной химии. Книга предназначена для специалистов по философии науки и техники, теории познания и онтологии, для студентов старших курсов, магистров, аспирантов, докторантов, преподавателей (...) философских и естественнонаучных дисциплин факультетов классических, педагогических и технологических университетов. (shrink)

In 1998, Clark and Chalmers articulated and defended the extended mind hypothesis. They argued, against the backdrop of functionalism about the mind, and for the specific case of the mental state type belief, that it is possible for a person's mind to extend out-side the boundary of their body. Departing from the framework of Indo-analytic comparative philosophy, we show that the Advaita Vedanta School of classical Indian philosophy, against the backdrop of a specific form of panpsychism, defended an account on (...) which a person's conscious experience, during an act of perceptual knowledge, is located outside the boundary of their body. Using the work of Adams and Maher on how to respond to Adams and Aizawa's coupling-constitution fallacy, we argue that the Advaita Vedanta account of mind can be taken to generate what we call the mind extension hypothesis -- the view that consciousness can extend outside of the body in perception. Recognizing the problematic nature of panpsychism as a metaphysical view about consciousness, we close by following work by Itay Shani on the real combination problem. We argue that the Advaita Vedanta account of panpsychism, as a kind of cosmopsychism, allows for a response to the so-called real combination problem proposed by Coleman. (shrink)